News ArticlesMultiplex tissue image of the month - CA6 in salivary glandThe glandular expression pattern of salivary gland-specific protein carbonic anhydrase 6 (gene: CA6) is highlighted by multiplex immunohistochemistry (mIHC/IF)...Read more Webinar: HCA Biological Networks Series: Reproduction NetworkOn May 13th the Human Cell Atlas will host a webinar focusing on the reproduction network in which HPA researcher Cecilia Lindskog will give a talk titled "A high-resolution spatio-temporal protein atlas of the human reproductive system"...Read more CD93 maintains vascular integrity and limits metastatic disseminationMetastasis formation is a multistep process that involves cancer cell transmigration through tumor vessels and through the healthy vasculature of the affected organ. This process is limited by an intact vascular barrier formed by endothelial cells, ECM, and pericytes. In a publication in JCI Insight, researchers from HPA and Uppsala University studied the role of the protein CD93 in maintaining vascular integrity in metastatic cancers...Read more Multiplex tissue image of the month - SGO1 in testisMultiplex immunohistochemistry (mIHC/IF) reveals nuclear expression of the protein Shugoshin 1 (gene: SGO1) in pachytene/diplotene spermatocytes - the early cell states of developing sperm cells...Read more GDF11 - Magic or Myth?GDF11, or Growth Differentiation Factor 11, rose to fame as a promising anti-aging molecule in 2013 when repletion in mice was shown to result in an age-related decline and reversal of cardiac hypertrophy (Loffredo, 2013). Subsequent studies further announced abilities to regenerate skeletal muscle and revascularize the brain (Sinha, 2014; Katsimpardi, 2014). In 2022, the biopharmaceutical company Elevian raised $58 million for GDF11 research, prompting a New York Times article titled "Can a 'Magic' Protein Slow the Aging Process?"..Read more |